背景描述
来源于已经发表的文献，是一篇分析散发性脑海绵状畸形出血风险因素的论文，可以用于数据分析来进行某种疾病结局的独立危险因素的考察。
文献题目：Modifiable cardiovascular risk factors in patients with sporadic cerebral cavernous malformations: obesity matters
文献摘要：
Objective
To assess the influence of modifiable cardiovascular risk factors on hemorrhage risk of sporadic cerebral cavernous malformations (CCMs).
Methods
From 1219 consecutive CCM patients (2003-2018), adult subjects with sporadic CCM and complete MRI were included. We evaluated presence of intracerebral hemorrhage (ICH) as mode of presentation, occurrence of ICH during follow-up and risk factors arterial hypertension, diabetes mellitus, hyperlipidemia, nicotine abuse, and obesity (BMI>30kg/m²). Impact of risk factors on ICH at presentation was calculated using univariate and multivariate logistic regression with age- and sex-adjustment. We performed Kaplan Meier and Cox regression to analyze cumulative 5-year-risk for (re-)bleeding.
Results
We included 682 CCM patients. The univariate logistic regression showed a significant relationship (OR=1.938, 95% CI: (1.120–3.353), p=0.018) between obesity and ICH as mode of presentation. Multivariate adjusted logistic regression confirmed significant correlation with OR=1.902 (95% CI: 1.024–3.532, p=0.042). Cox regression did not identify predictors for occurrence of (re-)hemorrhage (p>0.05; Hazard ratios: arterial hypertension 1.112 (95% CI: 0.622–1.990), diabetes 0.850 (95% CI: 0.208–3.482), hyperlipidemia 0.719 (95% CI: 0.261–1.981), nicotine abuse 1.123 (95% CI: 0.591–2.134), and obesity 0.928 (95% CI: 0.416–2.070)).
Conclusions
This study provides evidence that obesity may be a risk factor for CCM hemorrhage. It was significantly associated with ICH as mode of presentation. Other risk factors (arterial hypertension, diabetes mellitus, hyperlipidemia and current nicotine abuse) showed no such effect. None of the factors showed to be independent predictors for cumulative 5-year-risk of (re-)bleeding.
数据说明
样本量：其中682是CCM患者
字段：age, sex, incidental, Presentation with ICH(出现颅内出血), CCM related epilepsy（CCM癫痫），Mean duration of symptoms (range), mo (), arterial hypertension， diabetes mellitus, hyperlipidemia, nicotine abuse, and obesity (BMI>30kg/m²)， CCM location。
数据来源
datadryad
问题描述
独立危险因素的分析，Cox数据资料
